You may be able to achieve a remote initialization by creating a build project and running it from another machine with VisBuildPro on it that:
1) Gets the necessary files out of SourceSafe, either onto the remote box, or
1a) Uses the Copy Files action to deploy the install executables to the remote box.
2) Remotely execute the installers via psExec -- see the Server.bld sample. Things are a little tricker if the application you want to run remotely needs to display a GUI -- see 'Tutorials -> Samples -> Server.bld Sample' in the manual
http://www.kinook.com/VisBuildPro/Manual/ for more details.
3) Use the Write Registry action to remotely update the registry (supported in version 5.0). Of course, the Remote Registry service will need to be running on the remote computer.
4) Some of the built-in actions also support processing on a remote computer (for instance, COM+ and Service).