The LayoutX.dat files in
%APPDATA%\Roaming\Kinook Software\Ultra Recall
holds the pane layout info of the UR window (View | Layout on the menu).
https://kinook.com/UltraRecall/Manua...ustomizing.htm
And the LayoutAttribute in the .urd file is used to store the configuration of the columns in the Related Items pane. But there is (normally) nothing that would require the first column to be Item Title, whether rearranging via the mouse (drag/drop) or keyboard (Item | Show Columns, Move Up/Down), or that would prevent removing Item Title as a column. Now, it does appear to be a bug that F2 still edits, but in reality it will update the item title even if a different column is showing first.
If you could send your .urd file (or a pared down version of it that still demonstrates the issue) and the other items mentioned in the previous link, it would help when investigating the issue.