Large Database or Several Smaller DBs?

[J-Mac]

Which is more effective - keeping a lot of data in one URD, or creating several separate URD's?

I have a URD that I use for reference articles and I have several different topics in there as folders. It isn't terribly large yet; just about 100 MB. I am curious as to what user experience has shown - is it OK to just keep growing this database and continue adding folders to it? Or is it better to break this into a few URD's based on general categories.

at what size URD does URp begin to experience speed issues in opening, searching, etc. due to size and sheer volume of data?

Thank you.

Jim